Table 2.

Details of the patients who presented with optic neuritis and abnormal MRI at onset (n=12)

Age at onset (years)	Gender	Clinical presentation	Vision loss	MRI features at onset	Duration of follow-up (years)	Clinical outcome
16.0	Female	monosymptomatic	Unilateral	Multiple lesions; PVPOL, CWM	5.0	Multiple sclerosis
13.7	Female	monosymptomatic	Unilateral	Multiple lesions; PVPOL, CBL	10.2	Multiple sclerosis
12.1	Male	monosymptomatic	Unilateral	Two lesions; CWM and internal capsule	8.4	Multiple sclerosis
16.3	Male	monosymptomatic	Unilateral	Multiple lesions; PVPOL, SCWM, CC	0.7	Multiple sclerosis
16.9	Female	monosymptomatic	Bilateral	Multiple lesions; PVPOL, BS, CC, CBL, CWM	2.1	Multiple sclerosis
12.9	Female	monosymptomatic	Bilateral	Two lesions; Bilateral thalami (DGM)	2.3	Monophasic optic neuritis
9.1	Female	polysymptomatic	Bilateral	Multiple lesions of SCWM, CWM, DGM and BS	6.5	ADEM*
5.8	Male	polysymptomatic	Unilateral	Multiple lesions of SCWM, CWM, DGM	11.2	ADEM*
7.1	Male	polysymptomatic	Unilateral	Multiple lesions of CWM, CBL, CC	6.0	ADEM*
8.7	Female	polysymptomatic	Unilateral	Multiple lesions of CWM, SCWM, CBL	3.9	ADEM*
5.9	Male	Polysymptomatic Only child with encephalopathy	Unilateral	Bilateral diffuse lesion of posterior white matter	0.7	ADEM
12.0	Female	polysymptomatic	Unilateral	Single enhancing lesion of CBL	3.3	ADEM*

ADEM: acute disseminated encephalomyelitis, MRI: magnetic resonance imaging, CBL: cerebellum, CC: corpus callosum, CWM, central white matter, SCWM: subcortical white matter, BS: brainstem, DGM: deep gray matter, PVPOL: periventricular perpendicular ovoid lesion.

^*Because of the absence of encephalopathy, these patients are considered clinically isolated syndrome when pediatric consensus definitions are applied ⁷.