Figure 3.

Differential expression of selected miRNA in a large panel of cell lines. Abundant miRNA (A) and differentially expressed miRNA (B) selected from qRT-PCR profiling were evaluated on a panel of lymphoma cell lines. MiR-155, shown in (B), was both highly and differentially expressed in the initial profile. In (B), HL cell lines with a significantly higher miRNA expression in the initial screen on differential expression (Figure 1) are marked in red, whereas cell lines that contained a significantly lower expression of the given miRNA are marked in blue. Data for miR-206 and miR-153 were not shown because their expression was too low (C_t values >35) to be quantified reliably. Significant differences in a comparison between all groups were obtained by a Kruskal-Wallis test and are marked with asterisks next to the miRNA name. Asterisks within the plots indicate significant differences between Hodgkin cell lines and other categories specifically as found by Dunn's multiple comparison test. For both tests: *P < .05, **P < .01, and ***P < .001.