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. Author manuscript; available in PMC: 2009 Aug 26.
Published in final edited form as: Neuroscience. 2008 Jun 19;155(3):597–602. doi: 10.1016/j.neuroscience.2008.06.027

Fig. 3. Buprenorphine induced CPP in ORL1 receptor knockout mice but not in their wild-type littermates.

Fig. 3

Mice lacking the ORL1 receptor [ORL1 (−/−)] and their wild type littermates [ORL1 (+/+)] were tested for baseline place preference on day 1. Mice then received alternate-day saline/buprenorphine (3 mg/kg) or buprenorphine/ saline conditioning sessions on days 2 and 3. Mice were then tested for postconditioning preference on day 4. Data are expressed as mean (±SEM) of 9 mice per genotype. *indicates a significant increase in the amount of time that the mice spent in the drug-paired chamber on day 1 (p<0.05).