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. 2009 Jan 26;119(2):305–314. doi: 10.1172/JCI35958

Figure 7. Production of mature IL-1β in APAP hepatotoxicity.

Figure 7

Release of mature IL-1β requires transcription of pro–IL-1β and subsequent cleavage and secretion by activated caspase-1. In APAP hepatotoxicity, apoptotic mammalian DNA has been shown to increase transcription of pro–IL-1β via a Tlr9-dependent pathway, and caspase-1 has been shown to be activated via a Nalp3/ASC pathway. The identity of the presumed danger-associated molecules responsible for activating the Nalp3 inflammasome in APAP hepatotoxicity remains to be determined.