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. 2009 Jan 26;119(2):315–322. doi: 10.1172/JCI37432

Figure 2. Lipid profiles of patients with severe insulin resistance.

Figure 2

(A) Fasting serum TG and (B) cholesterol concentrations in patients with insulin receptoropathy, lipodystrophy, or idiopathic severe insulin resistance (IR). (C) Comparison of lipid profiles between diabetic and nondiabetic subjects with either genetic INSR defects presenting at or after puberty or severe insulin resistance of unknown, but likely genetic, etiology. No significant differences were detected by ANOVA. DS, Donohue syndrome; RMS, Rabson-Mendenhall syndrome; TA, post-pubertal severe insulin resistance due to genetic insulin receptor defects; TB, type B insulin resistance; PLD, familial partial lipodystrophy due to LMNA mutations; GLD, generalized lipodystrophy; SIR, severe insulin resistance. Dashed lines represent World Health Organization thresholds for the diagnosis of the metabolic syndrome for TG (>1.7 mmol/l) and HDL cholesterol (<1.0 mmol/l for females). Error bars represent SEM.