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. 2009 Jan;174(1):54–62. doi: 10.2353/ajpath.2009.080602

Figure 3.

Figure 3

A: HMGCR mRNA levels in control and post-I/R cortical kidney samples obtained at 4 or 72 hours after surgery were quantified by PCR. In both instances, an ∼30% increase in mRNA levels was observed (expressed as a ratio to GAPDH). B: RNA polymerase II (Pol II) densities were assessed at the HMGCR promoter, and at the start and end exons of the HMGCR gene (exons 1 and 19). I/R caused a small, albeit statistically significant, Pol II increase at the HMGCR promoter. Conversely, I/R induced an approximately threefold increase in Pol II at both exons 1 and 19. As expected, the absolute Pol II amounts in both the control and post-I/R kidneys were greater at the start versus the end exon.