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. 2009 Jan;174(1):54–62. doi: 10.2353/ajpath.2009.080602

Figure 4.

Figure 4

The HMGCR promoter region was probed for: i) sterol-responsive element binding proteins (SREBP 1, 2); ii) general transcription factors (NF-κB, c-FOS, c-Jun); and iii) two heat shock proteins (HSP-70 and HSP-32, ie, HO-1). I/R caused twofold to threefold increases in the densities of both SREBP 1 and 2 at the HMGCR promoter. Significantly greater amounts of NF-κB, c-Fos, c-Jun, HSP-70, and HO-1 were also observed in the I/R versus control kidneys. Thus, multiple factors appear to activate HMGCR transcription as part of the stress response.