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. 2009 Jan;174(1):177–183. doi: 10.2353/ajpath.2009.080342

Figure 1.

Figure 1

Effects of the peptide Ac2-26 and the Fpr antagonist Boc2 treatment on carrageenin-induced neutrophil influx. WT, AnxA1-null, and Fpr1-null mice were administered with carrageenin (CG4h) and peptide Ac2-26 (Ac2-26 + CG4h) as described in the Materials and Methods. A–C: The carrageenin administration induced a high incidence of intravascular (arrowheads) and extravascular (arrows) neutrophils. D, F, and G: Few intravascular neutrophils were observed after peptide Ac2-26 treatment (Ac2-26 + CG4h). E: WT mice administered with Boc2 (Boc2 + Ac2-26 + CG4h) showed a high incidence of extravascular neutrophils. Sections were 0.5 μm. Staining: toluidine blue. H: Statistical analysis. Data are mean ± SEM of n = 5 mice per group. ***P < 0.001 versus respective vehicle group; §P < 0.05 and §§P < 0.01 versus respective CG4h group; ##P < 0.01 versus respective Ac2-26 + CG4h group; xxP < 0.01 and xxxP < 0.001 versus respective group from WT mice. Scale bars = 5 μm.