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. 2009 Jan;174(1):228–238. doi: 10.2353/ajpath.2009.080764

Figure 1.

Figure 1

Cross-sectional analysis of soluble tau species in the rTg4510 mice. Representative immunoblots of soluble tau species from whole brains of 1-, 3-, 5.5-, and 9-month-old rTg4510 mice and 9-month-old non-transgenic (N) mouse as a control were normalized to GAPDH levels and quantified using pixel density. With the exception of pT212 tau, soluble phospho-tau species were at maximum levels at 1 month. In aged mice, a 64kDa tau species (as indicated on the right) appeared in the soluble fraction using antibodies against pS262/S356, pS202/T205, pS396/S404, pT231, and N-terminal tau.