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Cross-sectional analysis of insoluble tau species in the rTg4510 model. Representative immunoblots of sarkosyl insoluble tau species from whole brains of 1-, 3-, 5.5-, and 9-month-old rTg4510 mice. 64-kDa sarkosyl insoluble tau species was apparent at 5.5- and 9-month-old in rTg4510. Interestingly, considerable variability within age groups was observed with insoluble tau fractions.
