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Inhibition of AP-1 activity with Tam67 significantly prolongs survival of mice with experimental osteosarcoma metastasis. A: Doxycycline-induced Tam67 expression in K7M2 osteosarcoma cells resulted in an increase in survival (P < 0.0001 by log-rank test for K7M2-Tam67 −dox vs +dox). B: Constitutive Tam67 expression in K7M2 cells (K7M2-pCDNA-Tam67) results in a significant increase in survival compared to mice injected with K7M2 cells containing the empty vector (P < 0.005, n = 3).
