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. 2009 Jan;174(1):276–286. doi: 10.2353/ajpath.2009.080086

Figure 6.

Figure 6

PTEN, MYC, and IRS2 expression in human prostate. Human prostate with benign glandular hyperplasia (a, c, e) and invasive prostate cancer (b, d, f) labeled for PTEN (a, b), IRS2 (c, d), and MYC (e, f). PTEN shows a strong signal in benign prostatic glands (a) but is lost in most invasive cancer cells (b). Inversely, IRS2 shows a weak signal in few benign prostatic basal cells (arrow in c) and strong labeling of invasive cancer cells (d). Nuclear c-MYC was absent in benign prostatic glands (e), but strongly up-regulated in a fraction of invasive prostate cancer cells (arrows in f). Original magnifications, ×400.