Table 1.

Incidence of Invasive Neoplasms in Percent (Absolute Number in Parentheses) of Breast, Skin, Prostate, Endometrium, and Colon in Pten^+/− Mice

	150 to 330 days		150 to 400 days
Study period Genotype	Pten+/−Irs2+/+	Pten+/−Irs2−/−	Pten+/−Irs2+/+	Pten+/−Irs2+/−
Males (n)	9	9	30	14
Colon cancer	22% (2)	0	7% (2)	0
Prostate cancer	22% (2)	0	20% (6)	29% (4)
Skin cancer	11% (1)	0	10% (3)	0
Females (n)	14	10	20	32
Endometrial carcinoma	7% (1)	0	10% (2)	6% (2)
Skin cancer	14% (2)	0	15% (3)	9% (3)
Breast cancer	21% (3)	0	45% (9)	19% (6)
All animals (n)	23	19	50	46
Incidence for invasive neoplasms†	43% (10)	0*	44% (22)	28% (13)

The study period ranged from 150 to 330 days to compare Pten^+/−Irs2^+/+ with Pten^+/−Irs2^−/− mice and from 150 to 400 days to compare Pten^+/−Irs2^+/+ with Pten^+/−Irs2^+/− mice. Pten^+/+Irs2^+/+ (n = 16) and Pten^+/+Irs2^−/− (n = 12) controls never developed any neoplasms. 

^*P < 0.001 Fisher’s exact test. 

^†Five mice (one Pten^+/−Irs2^+/+ male, two Pten^+/−Irs2^+/+ females, and two Pten^+/−Irs2^+/− females) had two invasive neoplasms (ie, prostate and skin, breast and skin, or endometrial and breast cancer), which were counted as a single event to calculate incidence.