Table 2.
Incidence of Preinvasive Neoplasms in Percent (Absolute Number in Parentheses) in Pten+/− Mice
| 150 to 330 days
|
150 to 400 days
|
|||
|---|---|---|---|---|
| Study period Genotype | Pten+/−Irs2+/+ | Pten+/−Irs2−/− | Pten+/−Irs2+/+ | Pten+/−Irs2+/− |
| All animals (n) | 23 | 19 | 50 | 46 |
| Pheochromocytoma | 70% (16) | 47% (9) | 80% (40) | 83% (38) |
| Colon adenoma | 48% (11) | 58% (11) | 60% (30) | 76% (35) |
| Males (n) | 9 | 9 | 30 | 14 |
| PIN | 100% (9) | 77% (7) | 100% (30) | 100% (14) |
| Females (n) | 14 | 10 | 20 | 32 |
| EIN | 71% (10) | 70% (7) | 80% (16) | 81% (26) |
The study period ranged from 150 to 330 days to compare Pten+/−Irs2+/+ with Pten+/−Irs2−/− mice and from 150 to 400 days to compare Pten+/−Irs2+/+ with Pten+/−Irs+/− mice. Noninvasive tumors were found in prostate, uterus, colon, and adrenal medulla. No statistical differences were evident.