Table 1.

Drug-appropriate responding after administration of GHB in animals trained to discriminate other drugs.

Training drug (dose, route)	Maximum %DR after administration of GHB^*	N (%DR/total)^*	Species
Baclofen (3.2 mg/kg, ip)	77%	7/11	Rat (Sprague-Dawley)^a
D-amphetamine (0.56 or 1 mg/kg, ig)	29%	4/4	Rhesus monkey^b
Diazepam (1 mg/kg, ip)	3%	10/10	Rat (Sprague-Dawley)^a
Ethanol (1 g/kg, ig)	82%	6/6	Rat (Long Evans)^c
Ethanol (1 g/kg, ig)	60%	5/5	Rat (Long Evans)^d
Ethanol (2 g/kg, ig)	< 10%	5/5	Rat (Long Evans)^c
Ethanol (1.5 g/kg, ip)	7%	5/5	Mouse (C57BL/6J)^e
Ethanol (1.5 g/kg, ip)	2%	2/4	Mouse (DBA/2J)^e
Flumazenil (0.1 mg/kg im)	< 24%	7/7	Pigeon (Carneau)^f
Flumazenil (0.1 or 0.32 mg/kg sc)	7%	2/2	Rhesus monkey^b (5.6 mg/kg diazepam daily)
GBL (150 mg/kg, ip)	> 80%	8/8	Rat (Sprague-Dawley)^g
Heroin (0.3 mg/kg, sc)	20%	5/5	Rat (Sprague-Dawley)^h
PCP (2 mg/kg, ip)	25%	4/4	Rat (Sprague-Dawley)^h
PCP (2 mg/kg, ip)	1%	12/12	Rat (Sprague-Dawley)ⁱ
Pentobarbital (10 mg/kg, ig)	0%	3/3	Rhesus monkey^b
Pentylenetetrazol (20 mg/kg, ip)	100%	4/4	Rat (Long Evans)^j
THC (3.2 mg/kg, ip)	NR^**	2/10	Rat (Sprague-Dawley)^k
Triazolam (0.1 mg/kg, sc)	27%	3/3	Rhesus monkey^b
UMB 86 (100 mg/kg, ip)	1%	3/3	Rat (Sprague-Dawley)^l

The maximum %DR averaged across animals is reported when at least half of the animals responded. N is reported as the number of animals that responded (%DR) over the number of animals tested (total).

^**

NR – not reported, because less than half of the animals responded at the dose(s) studied.

Carter et al., 2004b;

Woolverton et al., 1999;

Colombo et al., 1995d;

Metcalf et al., 2001;

Shelton, 2004;

Koek et al., 2006a;

Baker et al., 2005;

Beardsley et al., 1996;

ⁱ

Koek et al., 2007a;

Shearman and Lal, 1980;

Browne and Weissman, 1981;

Carter et al., unpublished data.