Table 2.

Drug discrimination studies in which the putative antagonism of GHB by another drug was studied.

Training drug (dose, route)	Drug(s) studied with GHB	Species	% Decrease of GHB-appropriate responding
GHB (56 mg/kg, im)	CGP35348	Pigeon (Carneau)a	67%
	Ketamine		8%
GHB (100 mg/kg, im)	CGP35348		68%
	DTT		0%
	Ketamine		17%
GHB (178 mg/kg, im)	CGP35348		90%
	DTT		6%
	Flumazenil		17%
	Haloperidol		9%
	Ketamine		0%
	NCS-382		0%
GHB (100 mg/kg, im)	CGP35348	Pigeon (Carneau)b	76%
	Flumazenil		17%
	Haloperidol		17%
	Naltrexone		11%
	NCS-382		9%
GHB (100 mg/kg, im)	GHV	Pigeon (Carneau)c	13%
GHB (100 mg/kg, im)	3-HPA	Pigeon (Carneau)d	9%
	UMB 72		25%
	UMB 86		27%
GHB (200 mg/kg, ip)	CGP35348	Rat (Sprague-Dawley)e	64%
GHB (200 mg/kg, ip)	CGP35348	Rat (Sprague-Dawley)f	81%
	Flumazenil		16%
	NCS-382		54%
GHB (200 mg/kg GHB, ip) vs.	CGP35348	Rat (Sprague-Dawley)g	73%
saline or baclofen	CGP52432		82%
	DTT		33%
	NCS-382		44%
	UMB 86		18%
GHB (200 mg/kg GHB, ip) vs.	CGP35348		87%
saline, baclofen, or diazepam	CGP52432		93%
	DTT		62%
	NCS-382		37%
	UMB 86		50%
GHB (200 mg/kg, ip)	3-HPA	Rat (Sprague-Dawley)d	39%
	UMB 72		31%
	UMB 86		16%
GHB (200 mg/kg, ip)	GHV	Rat (Sprague-Dawley)c	39%
Baclofen (3.2 mg/kg, ip)	GHV		37%h
GHB (300 mg/kg GHB, ig) vs.	CGP35348	Rat (Sprague-Dawley)i	94%j
1 g/kg ethanol	NCS-382		79%
GHB (300 mg/kg, ig)	CGP35348	Rat (Sprague-Dawley)k	80%j
	NCS-382		45%
GHB (300 mg/kg, ig)	CGP35348	Rat (Long Evans)l	65%j
GHB (700 mg/kg, ig)	CGP35348		85%j
GHB (300 mg/kg, ig)	NCS-382	Rat (Long Evans)m	92%j
GHB (700 mg/kg, ig)	NCS-382		88%j
GHB (600 mg/kg, ig)	DTT	Rats (Long Evans)n	80%j
Baclofen (3.2 mg/kg, ip)	CGP35348	Rat (Sprague-Dawley)o	78%

^aKoek et al., 2006b;

^bKoek et al., 2004;

^cCarter et al., 2005a;

^dCarter et al., 2005b;

^eCarter et al., 2006a;

^fCarter et al., 2003;

^gKoek et al., 2005;

^hIn these studies;

ⁱBaker et al., 2008;

^jValues obtained using Graph Digitizer (Datatrend Software);

^kBaker et al., 2005;

^lColombo et al., 1998b;

^mColombo et al., 1995b;

ⁿCarai et al., 2004;

^oCarter et al., 2004a; dose of GHB antagonized was 200 mg/kg, ip.