Table 1.
Cytotoxicities of psymberin, mycalamide A, and analogs against various human tumor cell lines.a
| cmpd | IC50[nm] | |||
|---|---|---|---|---|
| KM12 | PC3 | SK-MEL-5 | T98G | |
| 1 | 0.45 ± 0.01 | 0.98 ± 0.12 | 2.29 ± 0.13 | 1.37 ± 0.06 |
| 3 | 0.95 ± 0.02 | 2.5 ± 0.2 | 3.79 ± 0.04 | 2.87 ± 0.07 |
| 5 | 37.1 ± 5.5 | 200.2 ± 27.6 | 352.0 ± 12.1 | 85.8 ± 48.4 |
| 6 | 126.08 ± 8.6 | 346.5 ± 102.8 | 762.8 ± 70.0 | 186.7 ± 51.3 |
| 18 | 710.9 ± 35.8 | 821.8 ± 89.1 | >1,000 | >1,000 |
| 19 | >1,000 | 255.5 ± 11.4 | >1,000 | >1,000 |
a
The Promega CellTiter GloTM assay was utilized to measure cell viability after cells were exposed to compounds for 48 h. IC50 values represent the mean of triplicate experiments ± standard error of the mean. KM12: colon tumor; PC3: prostate tumor; SK-MEL-5: melanoma; T98G: glioblastoma.