Table 1.
Dot/Icm proteins
| Protein | Comment/Function |
|---|---|
| Substrate Recognition | |
| IcmS36-38,40 | Substrate recognition/presentation to translocon |
| IcmW36-38,40 | Substrate recognition/presentation to translocon |
| LvgA36 | Substrate recognition/presentation to translocon |
| Coupling ATPase | |
| DotL/IcmO42,43 | ATPase /binds directly to substrates? |
| DotM/IcmP46,47 | ATPase component |
| DotN/IcmJ46,47 | Probable ATPase component |
| Core Components | |
| DotC47 | Putative outer membrane lipoprotein |
| DotD47 | Putative lipoprotein/localized to outer membrane |
| DotF/IcmB47 | Interacts with substrates/major component of channel? |
| DotG/IcmE47 | Major component of channel |
| DotH/IcmK47 | Outer membrane channel? |
| Core Stability Determinants | |
| DotU/IcmH50,51 | Inner membrane protein |
| IcmF50,51 | Inner membrane protein |
| Cytoplasmic Components | |
| IcmQ49 | Pore forming molecule |
| IcmR37,48 | Chaperone for IcmQ |
| DotB54,116 | ATPase/Disassembly of translocon? |
| DotO/IcmB117 | Cytoplasm/inner membrane |
| Inner Membrane or Periplasmic Components of Unknown Function | |
| DotA25,118 | Large polytopic inner membrane protein |
| DotE/IcmC47 | Similar to DotV |
| DotI/IcmL117 | Inner membrane |
| DotJ/IcmM | Predicted inner membrane |
| DotK/IcmN119 | Predicted inner membrane |
| DotP/IcmD | Predicted inner membrane |
| DotV47 | Predicted inner membrane |
| IcmT120 | Inner membrane protein |
| IcmV121 | Predicted inner membrane |
| IcmX122 | Periplasmic |