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. Author manuscript; available in PMC: 2009 Jan 27.
Published in final edited form as: J Nucl Med. 2006 Jun;47(6):1049–1058.

TABLE 1.

Statistical analysis of 210Po α–particle track distribution data (7) using Poisson, log normal (LN) and Poisson-log normal (P – LN) functions.

Labeling concentration
(kBq/mL)
Exposure Time
(d)
Function <n> (tracks/cell) σ § v χ̂2 R2
0.52 ± 0.051 52d Poisson } 6.7* 7 149
LN 0.81 6 3.2
P – LN 1.1 6 6.5
Constrained LS fit to LN 6.7* ± 1.1 0.80 ± 0.097 5 3.9 0.78
LS fit to LN 8.2 ± 1.7 0.88 ± 0.11 6 3.2 0.81

Convolved (52, 26, 7d) Poisson } 5.5 19 7.7E+07
LN 0.71 18 3.6
P – LN 0.96 18 12
LS fit to LN 7.1 ± 0.63 0.80 ± 0.056 18 3.1 0.92

3.8 ± 0.36 4 d Poisson } 7.3* 7 25
LN 0.64 6 0.5
P – LN 0.60 6 1.1
Constrained LS fit to LN 7.3* ± 0.32 0.61 ± 0.029 5 1.2 0.98
LS fit to LN 7.4 ± 0.33 0.62 ± 0.029 6 0.9 0.98

Convolved (0.67, 4d) Poisson } 6.1 16 1.2E+07
LN 0.62 15 2.8
P – LN 0.57 15 2.1
LS fit to LN 6.9 ± 0.22 0.59 ± 0.023 15 1.9 0.98

67 ± 6.6 1 d Poisson } 5.7* 7 1.1
LN 0.54 6 5.6
P – LN 0.28 6 0.66
Constrained LS fit to LN 5.7* ± 0.33 0.48 ± 0.044 5 15 0.88
LS fit to LN 6.5 ± 0.29 0.52 ± 0.033 6 9.5 0.95

Convolved (0.25, 1d) Poisson } 5.7 14 9.6E+06
LN 0.62 13 8.4
P – LN 0.49 13 1.7
LS fit to LN 6.7 ± 0.25 0.54 ± 0.029 13 6.3 0.97
*

The arithmetic mean <n> with * is decay corrected for t2 > t1, otherwise <n> is obtained from the raw data. σ, v are the log normal shape parameter and degrees of freedom, respectively. The values are shown upto two significant digits.

Errors are based on SD of triplicate measurements of scintillation counts and cell counts.

Standard Errors are provided by least-squares fit of the data to a LN function using SigmaPlot (SPSS).

§

Optimized value of σ (shape parameter) obtained via minimization of chi-square (χ̂2) procedure.