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. Author manuscript; available in PMC: 2009 Jan 27.
Published in final edited form as: J Am Chem Soc. 2007 Sep 22;129(41):12432–12438. doi: 10.1021/ja072311g

Figure 1.

Figure 1

The Bergman cycloaromatization exemplified by the C-1027 chromophore. Upon release from the apo-protein CagA, the enediyne core (shown in red) undergoes an electronic rearrangement to form a 3, 6-diradical species that can abstract hydrogen atoms from DNA. DSB, double-stranded break.