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. Author manuscript; available in PMC: 2009 Jan 27.
Published in final edited form as: J Am Chem Soc. 2007 Sep 22;129(41):12432–12438. doi: 10.1021/ja072311g

Figure 2.

Figure 2

Biosynthesis of (S)-3-chloro-4,5-dihydroxy-β-phenylalanine moiety (3) of C-1027 (1, boxed). (A) A sub-cluster of genes within the C-1027 gene cluster that encode biosynthetic proteins for 3 production and (B) proposed biosynthetic pathway for 3 from L-α-tyrosine (2) and structures of 1 and engineered analogs 7, 8, and 9.