Figure 4.

Imaging data of CRMO lesion involving left clavicle in a 7-year old girl (A). Pre-treatment imaging. Plain radiograph of the left clavicle demonstrates periosteal new bone formation (arrow). (B-C). Pre-treatment MRI: (B) Axial (fat-saturated, T2-weighted) and (C) post gadolinium MRI: Hyper-intense T2 signal with post-contrast enhancement is seen within the clavicle (arrow) with marked soft tissue inflammation (arrow). (D-E). Post-treatment MRI (5 months after initiation of treatment with pamidronate) with the same technique as B and C, respectively. The intra-osseous abnormal signal has significantly improved, and marked soft tissue abnormality has almost completely resolved. (F-G). Post-treatment MRI (8 months after initiation of treatment with pamidronate) with the same technique as B and C, respectively, reveals complete resolution of the intra-osseous abnormal signal.