Table 2.
Comparison of common results identified in different JAK/STAT modulator screens
| Gene | Baeg (FL/RL) | Müller (FL) | Müller (FL/RL) | Human homologue | |
|---|---|---|---|---|---|
| dome | * | − | − | − | gp130a |
| hop | * | − | − | − | JAK2b,d,g |
| stat92E | * | − | − | − | STAT5c,d,g |
| cdc2 | * | − | − | − | CDC2d,g |
| CG11700 | * | − | − | NC | UBCh |
| CG17836 | * | − | − | − | None |
| apt | + | + | + | None | |
| brm | * | + | − | − | SMARCA2g |
| CG15563 | + | − | NC | None | |
| CG30460 | + | − | NC | C8ORF70g | |
| enok | * | + | + | + | MYST3,dg |
| hsc70-4 | + | − | NC | HSPA8g | |
| ken | * | + | − | NC | BCL6e |
| mbl | + | − | NC | MBNL1d,g | |
| mor | * | + | − | − | SMARCC2d,g |
| proct | + | − | NC | None | |
| ptp61F | * | + | + | + | PTPN1d,g |
| samuel | + | − | + | SAMD11h | |
| socs36E | * | + | + | + | SOCS5f |
| ssdp | * | + | + | NC | SSBP3d,g |
Data from Baeg et al. (‘Baeg’) [54] and from Müller et al 2005 (‘Müller’) [53].
Minus symbols (−) indicate down-regulation, plus symbols (+) indicate up-regulation and NC indicates no change of the pathway reporter after RNAi according to the normalisation approach indicated in the respective columns. FL indicates changes for the pathway reporter, while FL/RL indicate changes of the pathway reporter after normalization to a co-reporter.
* indicates that the interaction was confirmed by an independent dsRNA [61].
Domains in the Dome protein have most homology with the IL-6R family of receptors, including gp130 and LIFR [1].
Binari and Perrimon [3]
Hou et al. [4].
Human homologene.
Arbouzova et al. [38].
Karsten et al. [10].
Inparanoid.
Best reciprocal BLAST search.