. Author manuscript; available in PMC: 2010 Mar 1.

Published in final edited form as: Cancer Causes Control. 2008 Sep 24;20(2):171–179. doi: 10.1007/s10552-008-9231-9

Table 4.

Interaction between the MDM2 SNP309 and the p53 Arg72Pro polymorphism on skin cancer risk

P53 Genotype	MDM2	T/T	T/G	G/G	P, trend

	Interaction on melanoma risk
Arg/Arg	Case/Controls	46/203	48/211	15/72
	Multivariate OR^a	1.00	0.97 (0.62–1.53)	0.86 (0.45–1.65)	0.79
	Multivariate OR^b	1.00	0.96 (0.60–1.53)	0.83 (0.42–1.62)	0.82
Arg/Pro or Pro/Pro	Case/Controls	46/169	42/136	13/42
	Multivariate OR^a	1.19 (0.75–1.88)	1.36 (0.84–2.18)	1.34 (0.66–2.70)	0.62
	Multivariate OR^b	1.17 (0.73–1.89)	1.43 (0.88–2.34)	1.38 (0.66–2.87)	0.46

	p, interaction, 0.40

	Interaction on SCC risk

Arg/Arg	Case/Controls	67/203	61/211	22/72
	Multivariate OR^a	1.00	0.87 (0.59–1.30)	0.93 (0.53–1.62)	0.73
	Multivariate OR^b	1.00	0.93 (0.62–1.41)	0.96 (0.54–1.70)	0.99
Arg/Pro or Pro/Pro	Case/Controls	47/169	57/136	22/42
	Multivariate OR^a	0.84 (0.55–1.29)	1.27 (0.84–1.92)	1.59 (0.88–2.86)	0.03
	Multivariate OR^b	0.90 (0.58–1.40)	1.40 (0.91–2.14)	1.65 (0.89–3.05)	0.05

	p, interaction, 0.07

	Interaction on BCC risk

Arg/Arg	Case/Controls	67/203	69/211	22/72
	Multivariate OR^a	1.00	0.99 (0.67–1.47)	0.93 (0.54–1.62)	0.90
	Multivariate OR^b	1.00	0.99 (0.66–1.48)	0.93 (0.52–1.65)	0.87
Arg/Pro or Pro/Pro	Case/Controls	52/169	58/136	21/42
	Multivariate OR^a	0.94 (0.62–1.42)	1.29 (0.85–1.95)	1.53 (0.85–2.78)	0.08
	Multivariate OR^b	0.97 (0.63–1.50)	1.37 (0.89–2.10)	1.52 (0.82–2.82)	0.10

	p, interaction, 0.17

Unconditional logistic regression adjusted for the age.

Unconditional logistic regression adjusted for the age, family history of skin cancer, the number of lifetime severe sunburns which blistered (none, 1–5, 6–11, >11), natural skin color, natural hair color, childhood tanning tendency, childhood sunburn reaction, and moles on arms.