Table 1.

Inhibition of [³H]SR141716A at CB1 Receptors

Cmpda	Code	ClogPb	Ki (nM)c
2	HS69	5.33	590 ± 170
7a	HS53-2	4.46	6,900 ± 1,300
7b	HS57-2	5.11	1,420 ± 266
8a	HS53-1	4.68	4,400 ± 760
8b	HS57-1	5.32	66 ± 7.0
9	HS60	4.69	54% d
10	HS57-3	5.68	180 ± 27
11	HS57-4	6.21	4.6 ± 0.012
12	HS57-5	6.70	NAe
13	HS57-6	7.62	NAe
14	HS57-8	6.83	11 ± 3.4
15	HS57-9	6.85	97 ± 55
16	HS57-7	7.23	240 ± 79

^aAll compounds were tested as the freebase.

^bSee Ref. 25.

^cAll values are the mean ± SEM of three experiments performed in triplicate.

^dPercent inhibition at 100µM.

^eNA: not available