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. 2009 Jan 20;65(Pt 2):134–139. doi: 10.1107/S090744490900081X

Figure 1.

Figure 1

A simple model of hypothesis-driven research in the experimental natural sciences. Prior knowledge leads to a question that can hopefully be answered by carrying out one or more experiments. The observations and the prior knowledge are combined to yield a hypothesis or model, which can be used to make falsifiable predictions. In the case of crystallography, the model consists of the parameterization and the optimal values derived for all parameters.