Table 2.
Cytotoxicity of deoxyharringtonine (2), β-lactone 79 and anhydroharringtonine (5).
| Cell Line | 2 IC50 [μM] | 79 IC50 [μM] | 5 IC50 [μM] |
|---|---|---|---|
| HL-60 | 0.02 | 2.68 | 22.7 |
| HL-60/RV+ | 0.22 | 21.8 | >100[a] |
| JURKAT | 0.04 | 5.71 | 42.99 |
| ALL3 | <0.1[b] | 1.47 | >100[a] |
| NCEB1 | 0.07 | 8.62 | >100[a] |
| JEKO | 0.08 | 10.48 | >100[a] |
| MOLT-3 | 0.02 | 2.68 | 26.83 |
| SKNLP | <0.1[b] | 6.46 | 5.34 |
| Y79 | 70.59 | >100[a] | >100[a] |
| PC9 | 0.03 | 4.23 | 29.08 |
| H1650 | 0.04 | 4.53 | n.a. |
| H1975 | 0.06 | 8.42 | n.a. |
| H2030 | 0.10 | 7.72 | n.a. |
| H3255 | 0.08 | 5.55 | n.a. |
| A431 | 0.06 | n.a. | n.a. |
| HeLa | 0.04 | n.a. | n.a. |
| TC71 | 0.06 | 12 | >100[a] |
| HTB-15 | 0.20 | 52 | >100[a] |
| WD0082 | 0.10 | 5 | >100[a] |
[a]
Highest compound concentration tested.
[b]
Lowest compound concentration tested and yielding 100% cellular killing.