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. Author manuscript; available in PMC: 2009 Jan 28.
Published in final edited form as: Nature. 2007 Apr 26;446(7139):1000–1007. doi: 10.1038/nature05813

Figure 3. Selected syntheses of tumour-associated sialylated glycosphingolipid oligosaccharides.

Figure 3

a, GM2, GD3 and GD2 have a similar trisaccharide core. b, Synthesis of GM2 tetrasaccharide through α-selective sialyl phosphite donor glycosylation. c, Synthesis of GD3 tetrasaccharide by thiosialoside glycosylation. Incorporation of the C5-trifluoroacetamide group in both donor and acceptor enhances efficiency of the coupling. Piv, pivaloyl (2,2,2-trimethylacetyl).