Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
METH and AMPH target distinct populations of DAT to stimulate a DAT-mediated increase in [Ca2+]i and DA efflux. Multiple phosphorylation/conformation states of DAT could exist. Two examples of these possible DAT populations are shown here. AMPH targets population A to stimulate DA efflux and [Ca2+]i release. METH targets population B of DAT that is an activity-permissive population to stimulate DA efflux and [Ca2+]i release.
