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. 2009 Jan 30;284(5):2978–2989. doi: 10.1074/jbc.M805298200

FIGURE 4.

FIGURE 4.

METH releases more DA from DAT-transfected cells. Experiments were performed as described in Fig. 3 with the difference that we used a fixed concentration of 10 μm AMPH or METH. A, METH increases in DAT-mediated whole-cell currents at all voltages compared with AMPH (p < 0.05). The right panel shows the expansion of A near the two reversal potentials fit to polynomials (solid lines). METH-induced whole-cell current reversed at -44.2 ± 0.68 (thick line), whereas AMPH-induced current reversed at -17.5 ± 2.08 (thin line) (n = 7–9, p < 0.05). B, METH mediates significantly greater DA efflux compared with AMPH. The right panel depicts the expansion of B near the two reversal potentials fit to polynomials (solid lines). For METH, the oxidative current initiated at -58.38 ± 0.8 (thick line), whereas the AMPH-mediated oxidative current initiated at -38.42 ± 0.3 (thin line) (n = 7–9 p < 0.05).