FIGURE 11.
Proposed mechanism of GR inactivation by 2-AAPA. The thiols of the cysteine residues at the active site react with 2-AAPA to form mono- and bisthiocarbamoylated enzymes, resulting in irreversible enzyme inhibition.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.