Table 5.

OR of ≥3-step retinopathy progression from baseline level during each pregnancy state

	Intensive treatment*			Conventional treatment†
Pregnancy state	OR	95% CI	P	OR	95% CI	P
Changed to intensive therapy  before conception but not yet pregnant‡	-	-	-	1.56	0.53–4.56	NS
Pregnant vs. not pregnant	1.37	0.56–3.33	NS	2.90	1.45–5.82	0.003
First trimester	-	-	-	1.93	0.57–6.61	NS
Second trimester	-	-	-	4.26	2.05–8.88	<0.001
Third trimester	-	-	-	2.56	0.91–7.26	NS
After pregnancy
0–6 months	1.54	0.81–2.95	NS	3.16	1.61–6.19	<0.001
6–12 months	1.38	0.65–2.90	NS	2.87	1.37–6.01	0.005
>12 months	0.65	0.31–1.36	NS	1.19	0.60–2.40	NS

Data are adjusted for time in study, baseline retinopathy status, age, duration of diabetes, screening HbA_1c, history of pregnancy, prior # DCCT, and current mean HbA_1c.

^*OR versus not pregnant

^†OR versus not pregnant and not changed to intensive therapy in preparation for conception

^‡unadjusted for first, second, or third trimester.