Figure 3. GI50 (concentration of drug at which 50% growth inhibition is seen) of various 17-allylamino-17-demethoxy geldanamycin formulations to MCF-7 human breast cancer cells*.
*Data are means±SD after 72-h incubation (each data point, n=3 experiments). +P<0.05 in comparison to 17-AAG-SSM.
17-AAG, 17-allylamino-17-demethoxy geldanamycin; SSM; sterically stabilized nanomicelles; VIP, vasoactive intestinal peptide; DMSO, dimethylsulfoxide