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Proposed model for fimE regulation by IscR under iron and iron-sulfur replete or iron and iron-sulfur limiting conditions. Induction of the FimE recombinase by apoIscR leads to inversion of the fimS region to the OFF position and decreases expression of the fimAICDFGH locus. Decreased expression of type I fimbriae diminishes biofilm formation under iron and iron-sulfur limiting conditions.
