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. 2008 Dec 1;77(2):877–884. doi: 10.1128/IAI.01017-08

FIG. 4.

FIG. 4.

Histological analysis of livers and spleens from BALB/c mice inoculated with S19, B. abortus 2308, S19 ΔvjbR::Kan, or PBS. In the livers, random distribution of inflammatory foci in mice vaccinated with either S19 (A) or 2308 (B) was observed (×10 magnification; ×40 magnification in the inset). Normal liver appearance was observed in mice inoculated with either S19 ΔvjbR::Kan (C) or PBS (D). Foci of inflammation are composed primarily of histiocytes. Scale bars in panels A and B, 100 μM; inset scale bars, 25 μM. In the spleens of mice vaccinated with either S19 (E) or 2308 (F), the white pulp is coalescing and enlarged, including marginal zones, and the formation of secondary lymphoid follicles is present (×4 magnification). There was minimal enlargement of the marginal zone in the mice vaccinated with either S19 ΔvjbR::Kan (G) or PBS (H). Scale bars in panels E to H, 200 μM.