TABLE 1.

Fine specificity of antibodies elicited by CS peptide injected s.c. followed by topical application of imiquimod

Expt no.	Immunogena	Peak IgG GMTb	CSP titerc	IFA IgG titerd
1	Branched (T1BT*)4	3.6 × 104	128	20,480
2	Branched (T1BT*)4	5.2 × 104	258	40,960
	Linear T1BT*	3.2 × 104	128	81,920
3	Linear T1BT*	4.0 × 104	64	20,480

^aTopical imiquimod was applied to the site of the peptide injected s.c. (50 μg/dose), administered at 2-week intervals using three doses of branched peptide (experiments 1 and 2) or four doses of linear peptide (experiments 2 and 3).

^bAssayed by ELISA using P. falciparum CS repeats (T1B)₄ as the antigen.

^cTiters were determined in pooled immune sera incubated with viable transgenic PfPb sporozoites expressing P. falciparum CS repeats.

^dTiters were determined in pooled sera reacted with air-dried P. falciparum sporozoites.