FIG. 3.
Effect of coadministration of human fH on bacteremia after i.p. challenge of infant rats. Each group consisted of 15 rats except the group given 0 μg of fH (n = 10). Bacteremia in blood cultures obtained 8 h after bacterial challenge with ∼7 × 103 CFU/rat of group B strain H44/76 was measured. The differences between the respective geometric (Geo.) means of the four treatment groups given 50, 10, 2, or 0 μg/rat of human fH were significant (P < 0.02; ANOVA). Rats treated with 50 μg of human fH had a higher geometric mean number of CFU/ml than controls treated with 50 μg of human C1 esterase inhibitor (Est. Inh.) (P < 0.005). CI, confidence interval.