FIG. 2.
Occurrence of proteins involved in the c-di-GMP signaling pathway in species of the order Rickettsiales. PleC-like sensor kinases, as represented by the protein APH_0944 of A. phagocytophilum and the di-guanylate cyclase PleDAp (represented by APH_0551), are present in all species. A putative PDE (exemplified as protein RP246 from Rickettsia prowazekii) is only present in species of the genus Rickettsia. Abbreviations: RP, R. prowazekii; RT, Rickettsia typhi; RC, Rickettsia conorii; RF, Rickettsia felis; RB, Rickettsia bellii; OT, Orientia tsutsugamushi; wMel, Wolbachia from Drosophila melanogaster; wBM, Wolbachia from Brugia malayi; AM, Anaplasma marginale; AP, Anaplasma phagocytophilum; EC, Ehrlichia chaffeensis; ER, Ehrlichia ruminantium; NS, Neorickettsia sennetsu; T/O, vertical (transovarial) transmission from mother to offspring. In the “Genome” column, circles represent genomes and plasmids and are proportioned to show their relative sizes. (Modified from Trends in Genetics [5] with permission of the publisher.)