Skip to main content
. 2009 Jan 1;23(1):24–36. doi: 10.1101/gad.1753809

Figure 1.

Figure 1.

Hedgehog pathway components are deregulated in PDAC lesions. (A) Expression of Shh, Ptch1, Smo, and Gli1 mRNA in total RNA extracts from ∼12-wk-old LSL-Kras/+; p53F/+ control pancreata (P) (N = 3) or p48-Cre/+; LSL-Kras/+; p53F/+ tumors (T) (N = 3). Levels of mRNAs expressed as a percentage of the mGus control mRNA. Asterisk indicates a P-value <0.01. (B,C) Immuno-histochemical detection of Shh (50×). (B) No Shh detected in normal pancreas. (C) Shh expression detected inside ductal cells in PanIN lesions of 9-wk-old PDAC mice. The panels are representative of multiple fields of pancreatic sections from two control and two PDAC mice.