Table 2.
Comparison of Baseline Information of Individuals Who Had Converted to Psychosis at 1-Year Follow-up Versus Those Who Had Not
| At-Risk Subjects | Nonconverted (N = 34) | Converted (N = 6) | χ2 or t38 | p |
| Age (SD) | 18.3 (4.6) | 19.5 (3.0) | 0.61 | NS |
| Education (SD) | 10.7 (3.0) | 11.0 (1.7) | 0.23 | NS |
| Gender (male:female) | 21:13 | 2:4 | 1.69 | NS |
| Antipsychotic medication % | 21 | 67 | 5.43 | 0.02 |
| Psychotropic medication % | 56 | 83 | 1.60 | NS |
| Family history of psychosis % | 26 | 0 | 2.05 | NS |
| SPD diagnosis % | 47 | 33 | 0.39 | NS |
| Substance abuse history % | 29 | 83 | 6.33 | .012 |
| Comorbid mood disorder % | 53 | 33 | 0.78 | NS |
| Comorbid anxiety disorder % | 35 | 17 | 0.81 | NS |
| SIPS Positive Symptoms total (SD) | 10.1 (4.5) | 15.7 (4.7) | 2.81 | 0.008 |
| Unusual thought content | 2.7 (1.6) | 4.5 (1.4) | 2.63 | 0.012 |
| Suspiciousness | 1.9 (1.5) | 4.5 (1.2) | 4.05 | 0.000 |
| Grandiose ideas | 1.3 (1.6) | 1.7 (2.1) | 0.47 | NS |
| Perceptual abnormalities | 2.7 (2.1) | 2.2 (0.8) | 0.58 | NS |
| Disorganized communication | 1.4 (1.3) | 2.8 (1.5) | 2.42 | 0.021 |
| SIPS Negative Symptoms total (SD) | 9.5 (6.6) | 15.2 (8.6) | 1.85 | 0.07 |
| Social anhedonia or withdrawal | 1.7 (1.5) | 2.8 (2.0) | 1.66 | NS |
| Avolition | 2.0 (1.7) | 2.3 (1.2) | 0.42 | NS |
| Decreased expression of emotion | 1.4 (1.8) | 2.5 (1.8) | 1.35 | NS |
| Decreased experience of self | 0.9 (1.2) | 3.0 (2.3) | 3.38 | 0.002 |
| Decreased ideational richness | 0.9 (1.4) | 2.2 (1.5) | 2.17 | 0.036 |
| Deterioration in role functioning | 2.3 (1.8) | 2.7 (2.2) | 0.46 | NS |
| SIPS Disorganized Symptoms total (SD) | 6.2 (3.9) | 8.3 (5.1) | 1.16 | NS |
| Odd behavior or appearance | 1.4 (1.5) | 2.7 (1.8) | 1.85 | NS |
| Bizarre thinking | 1.5 (1.4) | 2.2 (1.7) | 1.04 | NS |
| Trouble with focus and attention | 1.9 (1.4) | 2.5 (1.5) | 0.87 | NS |
| Personal hygiene/social attentiveness | 1.2 (1.6) | 1.0 (1.3) | 0.26 | NS |
| SIPS General Symptoms total (SD) | 5.9 (4.0) | 8.8 (6.5) | 1.51 | NS |
| Sleep disturbance | 1.2 (1.3) | 2.0 (2.3) | 1.24 | NS |
| Dysphoric mood | 2.0 (1.5) | 2.8 (2.1) | 1.20 | NS |
| Motor disturbances | 0.9 (1.4) | 0.8 (1.0) | 0.13 | NS |
| Impaired tolerance to normal stress | 1.6 (1.7) | 3.0 (2.4) | 1.72 | NS |
| Global SAPS (SD) | 5.2 (2.7) | 8.0 (4.0) | 2.2 | 0.035 |
| Hallucinations | 1.6 (1.4) | 1.3 (0.8) | 0.37 | NS |
| Delusions | 1.9 (1.0) | 2.8 (1.0) | 2.15 | 0.038 |
| Bizarre behavior | 0.9 (1.1) | 1.3 (1.5) | 0.86 | NS |
| Formal thought disorder | 0.8 (1.2) | 2.3 (1.4) | −2.8 | 0.008 |
| Global SANS (SD) | 5.9 (4.1) | 8.5 (4.2) | –1.8 | NS |
| Affective blunting | 1.5 (1.5) | 2.7 (0.5) | –1.84 | NS |
| Alogia | 0.4 (0.9) | 1.0 (1.7) | –1.29 | NS |
| Avolition | 1.7 (1.2) | 1.7 (1.4) | 0.12 | NS |
| Anhedonia | 1.9 (1.4) | 2.3 (1.2) | –0.66 | NS |
| Attention | 0.3 (0.9) | 0.8 (1.3) | –1.37 | NS |
| BPRS Total (SD) | 14.8 (5.4) | 23.8 (2.6) | –4.0 | 0.000 |
| Thought disorder | 5.9 (3.3) | 10.0 (2.4) | –2.94 | 0.006 |
| Withdrawal-retardation | 3.8 (3.5) | 9.2 (3.9) | –3.44 | 0.001 |
| Anxious-depression | 5.3 (2.9) | 6.7 (3.9) | –0.99 | NS |
| Hostile-suspicious | 3.2 (2.0) | 4.7 (2.2) | –1.60 | NS |
| Activation | 1.1 (1.2) | 3.5 (2.4) | –4.02 | 0.000 |
| GAF (SD) | 53.3 (12.2) | 52.5 (7.5) | 0.15 | NS |
Note: SPD = Schizotypal Personality Disorder; SIPS = Structured Interview for Prodromal Syndromes; SAPS = Scale for the Assessment of Positive Symptoms; SANS = Scale for the Assessment of Negative Symptoms; BPRS = Brief Psychiatric Rating Scale; GAF = Global Assessment of Functioning.