Table 2.
Study Design Characteristics and Associated Mean (+ SD) Effect Sizes
| Design characteristic | n of Studies (%) | n of Effect Sizes | Mean Effect Size (SD) |
| Diagnostic System for Probands | |||
| Research Diagnostic Criteria | 7 (12) | 37 | 0.28 (0.35) |
| Diagnostic and Statistical Manual of Mental Disorders, 3rd ed. | 2 (3) | 8 | 0.37 (0.43) |
| Diagnostic and Statistical Manual of Mental Disorders, 3rd ed.—revised | 31 (54) | 157 | 0.38 (0.35) |
| International Classification of Diseases, 9th revision | 1 (2) | 1 | −0.08 (−) |
| Diagnostic and Statistical Manual of Mental Disorders, 4th ed. | 14 (24) | 74 | 0.45 (0.37) |
| Operational Criteria for Psychotic Illness | 3 (5) | 8 | 0.34 (0.26) |
| Type of First-Degree Relatives | |||
| Siblings | 17 (29) | 63 | 0.41 (0.38) |
| Parents | 6 (10) | 27 | 0.45 (0.31) |
| Offspring | 3 (5) | 9 | 0.36 (0.26) |
| Monozygotic twins | 1 (2) | 18 | 0.42 (0.30) |
| Parents and siblings | 11 (19) | 69 | 0.39 (0.35) |
| Siblings and offspring | 1 (2) | 20 | 0.35 (0.23) |
| Parents, siblings, and offspring | 10 (17) | 53 | 0.25 (0.35) |
| Not reported | 9 (16) | 26 | 0.53 (0.47) |
| Groups Matched on Age | |||
| Yes | 45 (78) | 224 | 0.36 (0.35) |
| No | 11 (19) | 55 | 0.48 (0.40) |
| Not reported | 2 (3) | 6 | 0.27 (0.28) |
| Groups Matched on Education | |||
| Yes | 36 (62) | 167 | 0.34 (0.36) |
| No | 9 (16) | 66 | 0.45 (0.29) |
| Not reported | 13 (22) | 52 | 0.45 (0.41) |
| Presence of Schizotypal Symptomsa | |||
| Yes | 21 (36) | 102 | 0.39 (0.30) |
| No | 20 (35) | 120 | 0.35 (0.36) |
| Not reported | 17 (29) | 63 | 0.43 (0.42) |
| Asymmetric Inclusion Criteria | |||
| Yes | 21 (36) | 115 | 0.44 (0.40) |
| No | 30 (52) | 134 | 0.34 (0.32) |
| Not reported | 7 (12) | 36 | 0.36 (0.32) |
“Yes” indicates that schizotypy was assessed and elevated rates of symptoms/schizotypal personality diagnoses were reported in the relative group; “no” indicates that schizotypy was assessed and either screened out of the relative group or reported as not significantly elevated compared to controls; “not reported” indicates that no assessment of schizotypy was described.