Table 2.
Primary Outcome Variables by Diagnosis of Psychotic Spectrum Disorder
| Interaction (treatment contrast by psychotic spectrum disorder) |
|||||||||||||
| Disulfiram/Naltrexone (mean, SD) | Disulfiram/Placebo (mean SD) | Naltrexone (mean SD) | Placebo (mean SD) | By Diagnosis (df = 1,243) (t, P) | DNd vs DPd (t, P) | DPd vs Nd (t, P) | Any medication vs Pd (t, P) | ||||||
| Alcohol-use outcomesa | |||||||||||||
| Maximum consecutive days of abstinence | 2.05, .04 | 0.79, .43 | 1.47, .14 | 1.50, .14 | |||||||||
| Psychotic spectrum (n = 66) | 69.2 (20.8) | 61.1 (28.8) | 67.6 (26.1) | 47.2 (34.3) | |||||||||
| Nonpsychotic spectrum (n = 185) | 68.8 (25.5) | 75.3 (20.2) | 66.7 (25.8) | 64.8 (28.3) | |||||||||
| Total days abstinentb | 3.23, .00 | 1.07, .29 | 0.90, .37 | 2.80, .01 | |||||||||
| Psychotic spectrum (n = 59) | 77.4 (12.8) | 78.8 (11.6) | 80.4 (7.0) | 68.4 (18.8) | |||||||||
| Nonpsychotic spectrum (n = 164) | 82.3 (4.0) | 81.6 (8.3) | 79.6 (11.4) | 80.8 (8.6) | |||||||||
| Total number of heavy drinking days | 2.93, .00 | 1.41, .16 | 0.81, .42 | 2.31, .02 | |||||||||
| Psychotic spectrum (n = 66) | 6.06 (11.5) | 4.16 (10.8) | 2.75 (5.7) | 11.57 (15.6) | |||||||||
| Nonpsychotic spectrum (n = 185) | 1.21 (2.9) | 2.20 (8.1) | 3.64 (10.8) | 2.58 (7.6) | |||||||||
| OCDS total score change over timec | n | n | n | n | z, P | z, P | z, P | z, P | Time z, P | ||||
| Pre | |||||||||||||
| Psychotic spectrum (n = 52) | 9.00 (7.4) | 13 | 14.2 (7.8) | 13 | 10.9 (4.9) | 14 | 14.3 (8.9) | 12 | 1.06, .29 | 1.60, .11 | 0.77, .44 | 0.21, .83 | −10.53, .00 |
| Nonpsychotic spectrum (n = 160) | 15.2 (8.9) | 39 | 10.5 (8.6) | 43 | 13.2 (7.8) | 37 | 15.7 (7.9) | 41 | |||||
| Post | |||||||||||||
| Psychotic spectrum (n = 50) | 6.0 (10.4) | 13 | 5.3 (4.4) | 12 | 8.4 (9.3) | 14 | 5.6 (9.1) | 11 | |||||
| Nonpsychotic spectrum (n = 158) | 5.9 (6.9) | 38 | 3.8 (5.9) | 43 | 5.2 (6.5) | 37 | 4.7 (7.5) | 40 | |||||
Note: OCDS = Obsessive Compulsive Drinking Scale.
a
The alcohol outcome measures were calculated from the TLFB for the entire treatment period of 12 weeks or 84 days.
b
df = 1,215.
c
Statistics from the OCDS analyses represent the treatment contrast by psychotic spectrum disorders by time effects.
d
DN is disulfiram and naltrexone group, DP is disulfiram and placebo group, N is naltrexone group, and P is placebo group.