. 2006 Nov 8;33(4):1038–1053. doi: 10.1093/schbul/sbl051

Table 4.

Double-Blind Controlled Trials Investigating Antipsychotic Effects on PS in Schizophrenia

Study	Diagnosis	Subjects	Mean Age (y)	Sample Size	Trial Duration (wk)	Medication Groups + Mean Dose Ranges	Psychomotor Measures	Main Findings
Kern et al¹⁰²	Schizophrenia	Treatment resistant	40	56	8	Risperidone (6–7 mg/d) and haloperidol (15–19 mg/d)	Pin test and pursuit rotor	Patients on risperidone performed significantly better on pin test. No significances on pursuit-rotor task.
Purdon et al¹⁰⁸	Schizophrenia	Within 5 y of first neuroleptic exposure	29	65	52	Olanzapine (5–20 mg), haloperidol (5–20 mg), and risperidone (4–10 mg)	Grooved Pegboard and FTT	Within group: improvement with olanzapine on pegboard. Between group: olanzapine > haloperidol on both tasks, olanzapine > risperidone on pegboard.
Purdon et al¹³²	Schizophrenia	Chronic patients	34	25	26	Quetiapine (468.2 mg/d) and haloperidol (15.5 mg/d)	FTT and Grooved Pegboard	Only 11 patients completed the full study. No significant differences between and within groups on any of the psychomotor measures.
Bilder et al³⁰	Schizophrenia and schizoaffective disorder	Treatment resistant	41	101	14	Clozapine (452 mg/d), haloperidol (19.6 mg/d), olanzapine (20.2 mg/d), and risperidone (8.3 mg/d)	FTT	Significant improvement over time for clozapine for fine motor functioning factor. No group × time interactions.
Green et al¹³³	Schizophrenia and schizoaffective disorder	Stable outpatients	43	62	104	Risperidone (6.1–5.7 mg/d) and haloperidol (5.2–4.5 mg/d)	Pin test	Pin test was part of memory and fluency factor in analysis. No between-group differences in any of the cognitive cluster scores.
Keefe et al¹³⁴^,¹³⁵	Schizophrenia, schizoaffective disorder, and schizophreniform disorder	First-episode patients	24	167	52	Olanzapine (9.6–11.3 mg/d) and haloperidol (4.6–4.8 mg/d)	FTT	No improvement in either medication group after 12 or 52 wk.
Keefe et al¹³⁶	Schizophrenia and schizoaffective disorder	Chronic in- and outpatients	39	414	52	Olanzapine (n = 159), risperidone (n = 158), and haloperidol (n = 97)	Grooved Pegboard	Significant improvement in the risperidone and olanzapine groups but not in the haloperidol group at 52 wk.

Note: FTT = finger-tapping test and PS = psychomotor slowing.