Table 2.
Study Reference | n | Duration of Illness | Age at Initial Scan, Mean (SD) | Follow-up, Mean (SD) | Findingsa |
James et al35 | 16 patientsb,16 controls | M: 1.95 yrs., F: 1.04 yrs. | Patients 16.6 (1.9) yrs., controls 16.0 (2.0) yrs. | Patients 2.7 (1.7) yrs., controls 1.7 (0.5) yrs. | B: Significant generalized ventricular enlargement (greater in males), greater left temporal horn, and smaller left amygdala; FU: no evidence of progressive structural brain changes. |
James et al34 | 16 patientsb, 16 controls | Same as above | Same as above | Same as above | B: Smaller prefrontal cortex and thalamus vol, larger fourth ventricle vol, no significant changes in cerebellum vol; FU: no progressive changes except decrease in the posterior-inferior vermis vol. |
S. Reig, C. Moreno, D. Moreno, M. Burdalo, J. Janssen, M. Parellada, A. Zabala, M. Desco, C. Arango, submitted | 21 patientsc, 34 controls | 3.2 (3) mo. | Patients 15.7 (1.7) yrs., controls 15.2 (1.4) yrs. | Patients 24.2 (1.0) mo., controls 24.2 (0.5) mo. | B: smaller frontal GM vol and larger frontal CSF vol in both hemispheres in males; FU: significant decrease in right and left frontal GM and increase in frontal left CSF in males. |
Note: M, males; F, females; CSF, cerebrospinal fluid; yrs., years; mo., months.
All significant findings relative to healthy controls.
Adolescent-onset schizophrenia.
Includes schizophrenia and nonschizophrenia psychotic disorders.