Table 2.

Volumetric Results From Longitudinal MRI Studies of Adolescent-Onset Psychosis

Study Reference	n	Duration of Illness	Age at Initial Scan, Mean (SD)	Follow-up, Mean (SD)	Findingsa
James et al35	16 patientsb,16 controls	M: 1.95 yrs., F: 1.04 yrs.	Patients 16.6 (1.9) yrs., controls 16.0 (2.0) yrs.	Patients 2.7 (1.7) yrs., controls 1.7 (0.5) yrs.	B: Significant generalized ventricular enlargement (greater in males), greater left temporal horn, and smaller left amygdala; FU: no evidence of progressive structural brain changes.
James et al34	16 patientsb, 16 controls	Same as above	Same as above	Same as above	B: Smaller prefrontal cortex and thalamus vol, larger fourth ventricle vol, no significant changes in cerebellum vol; FU: no progressive changes except decrease in the posterior-inferior vermis vol.
S. Reig, C. Moreno, D. Moreno, M. Burdalo, J. Janssen, M. Parellada, A. Zabala, M. Desco, C. Arango, submitted	21 patientsc, 34 controls	3.2 (3) mo.	Patients 15.7 (1.7) yrs., controls 15.2 (1.4) yrs.	Patients 24.2 (1.0) mo., controls 24.2 (0.5) mo.	B: smaller frontal GM vol and larger frontal CSF vol in both hemispheres in males; FU: significant decrease in right and left frontal GM and increase in frontal left CSF in males.

Note: M, males; F, females; CSF, cerebrospinal fluid; yrs., years; mo., months.

^aAll significant findings relative to healthy controls.

^bAdolescent-onset schizophrenia.

^cIncludes schizophrenia and nonschizophrenia psychotic disorders.