Table 2.

Studies Examining Lateral Ventricular Brain Size Longitudinally in Schizophrenia in Chronological order

Study	Scanner	No. of Patients	No. of Controls	Stage of Illness at Baseline	Years of Follow-up	Findings
Nasrallah et al. (1986)39	CT	11	0	Chronic schizophrenia	3	No change
Vita et al. (1988)40	CT	15	0	Chronic schizophrenia	2–5	No change
Kemali et al. (1989)41	CT	18	8	Chronic schizophrenia	3	Increased ventricles in one-third of patients
Woods et al. (1990)42	CT	9	0	Chronic schizophrenia	1–4.5	Increased ventricles in 8/9 patients
Degreef et al. (1991)43	MRI	18	8	First-episode schizophrenia	1–2	No change
DeLisi et al. (1991, 1992, 1995, 1997, 2004)44–48	MRI	50	20	First-episode schizophrenia	4–5	Increased ventricles
		26	10		10	Increased ventricles
Sponheim et al. (1991)49	CT	15	0	First-episode schizophrenia	1–3	No change
Jaskiw et al. (1994)50	CT	7	0	First-episode schizophrenia	5–8	No change
Vita et al. (1994)51	CT	9	0	First-episode schizophrenia	2–4	No change
Nair et al. (1997)52	MRI	18	5	Chronic schizophrenia	1.1–3.8	Increased ventricles—poor outcome only
Davis et al. (1998)53	CT	53	13	Chronic schizophrenia	5	Increased ventricles—poor outcome patients only
Rapoport et al. (1997)54	MRI	16	24	Chronic childhood schizophrenia	1.5–4	Increased ventricles
Illowsky et al. (1998)55	CT	13	0	Chronic schizophrenia	7–9	No change
Lieberman et al. (2001)56	MRI	51	13	First-episode schizophrenia	1–2	Increased Ventricular size associated with poor outcome
Mathalon et al. (2001)57	MRI	24	25	Chronic schizophrenia	0.7–7.5	Increased CSF
Saijo et al. (2001)58	MRI	15	12	Chronic schizophrenia	10	Increased ventricles
Cahn et al. (2002)59	MRI	34	36	First-episode schizophrenia	1	Increased ventricles
James et al. (2002)60	MRI	16	16	First-episode childhood schizophrenia	1.7–2.7	No change
Ho et al. (2003)61	MRI	73	23	First-episode schizophrenia	3	Increased CSF

Note: CT, computerized tomography; MRI, magnetic resonance imaging; CSF, cerebrospinal fluid.