Table 1.
Comparison of Early Responders and Nonresponders on Baseline Demographic and Clinical Characteristics
| Variable | Responders at 2 wk, N = 98 | Nonresponders at 2 wk, N = 345 | P Value |
| Mean age (SD) | 44.0 (14.2) | 43.5 (11.3) | .975 |
| Gender: % male | 58.2 | 62.9 | .505 |
| Race | .335 | ||
| Caucasian | 52 (53%) | 200 (58%) | |
| African American | 37 (38%) | 105 (30%) | |
| Other | 9 (9%) | 40 (12%) | |
| Married | 16 (16%) | 52 (15%) | .988 |
| Currently employed | 17 (17%) | 63 (18%) | .972 |
| Mean prior episodes | 6.2 (6.7) | 6.7 (9.7) | .959 |
| Past year psychiatric hospital duration | .826 | ||
| None | 71 (72%) | 243 (72%) | |
| <1 mo | 19 (19%) | 57 (17%) | |
| 1 mo plus | 8 (8%) | 38 (11%) | |
| Mean PANSS total score, mean (SD) | 89.8 (21.6) | 84.4 (20.1) | .023 |
| PANSS positive subscale mean (SD) | 22.5 (6.5) | 21.6 (6.2) | .201 |
| PANSS negative subscale mean (SD) | 221 (6.5) | 209 (7.2) | .131 |
| PANSS disorganized thoughts subscale mean (SD) | 21.9 (6.5) | 21.0 (6.2) | .225 |
| PANSS impulsivity/hostility subscale mean (SD) | 9.7 (3.8) | 8.6 (3.6) | .004 |
| PANSS anxiety/depression subscale mean (SD) | 13.6 (4.5) | 12.3 (4.1) | .010 |
| Remitteda at baseline, n (%) | 11 (11%) | 33 (10%) | .244 |
| Inpatient during randomization | 2 (2%) | 18 (5%) | .312 |
| Duration of psychiatric diagnosis (y) | 21.4 (13.9) | 21.3 (11.7) | .959 |
| Age at onset of diagnosis | 22.6 (9.7) | 22.1 (9.1) | .959 |
| Assigned treatment n (%) | .886 | ||
| Olanzapine | 36 (37) | 129 (37) | |
| Risperidone | 34 (35) | 105 (30) | |
| Conventional antipsychotics | 28 (28) | 111 (32) | |
| SF-36b bodily pain | −0.32 | −0.32 | .858 |
| SF-36b general health | −0.48 | −0.61 | .225 |
| SF-36b mental health | −0.95 | −0.88 | .891 |
| SF-36b physical functioning | −0.72 | −0.72 | .546 |
| SF-36b role—emotional | −0.81 | −0.94 | .484 |
| SF-36b role—Physical | −0.56 | −0.81 | .059 |
| SF-36b social functioning | −0.89 | −1.00 | .243 |
| SF-36b vitality | −0.63 | −0.55 | .721 |
| SF-36b physical heath component score | −0.34 | −0.48 | .109 |
| SF-36b mental health component score | −0.95 | −0.92 | .976 |
| Health insurance | .363 | ||
| Medicaid | 37 (38%) | 130 (40%) | |
| Medicare | 28 (29%) | 93 (28%) | |
| Private insurance | 19 (20%) | 37 (11%) | |
| Other insurance | 0 (0%) | 17 (5%) | |
| Uninsured | 13 (13%) | 52 (16%) |
Note: PANSS, Positive and Negative Syndrome Scale; SF-36, Medical Outcome Survey-Short Form 36.
a
Remitted (severity criteria) defined as mild or better scores (≤3) on 8 PANSS items (P1, P2, P3, N1, N4, N6, G5, G9).18
b
Standardized SF-36 score relative to general population norms.