Table 3.
Schizophrenia Hazard Ratio associated with Antibody Levels in Multiagent Models by Sex and Racea
Factor | Hazard Ratiob | 95% Confidence Interval | P Value |
Men | |||
HSV-1 | 1.03 | 0.90, 1.17 | .71 |
HSV-2 | 0.97 | 0.84, 1.12 | .63 |
CMV | 0.90 | 0.78, 1.03 | .12 |
EBV | 0.92 | 0.81, 1.04 | .17 |
VZV | 0.99 | 0.87, 1.13 | .91 |
HHV-6 | 1.17 | 1.03, 1.33 | .01 |
Women | |||
HSV-1 | 1.01 | 0.70, 1.47 | .95 |
HSV-2 | 0.69 | 0.52, 0.92 | .01 |
CMV | 0.62 | 0.44, 0.89 | .01 |
EBV | 1.02 | 0.70, 1.48 | .93 |
VZV | 1.11 | 0.79, 1.57 | .55 |
HHV-6 | 1.08 | 0.70, 1.66 | .74 |
White | |||
HSV-1 | 0.84 | 0.70, 1.01 | .07 |
HSV-2 | 0.97 | 0.80, 1.19 | .80 |
CMV | 1.05 | 0.88, 1.25 | .60 |
EBV | 0.94 | 0.80, 1.11 | .47 |
VZV | 0.98 | 0.83, 1.16 | .80 |
HHV-6 | 1.14 | 0.97, 1.33 | .12 |
Black | |||
HSV-1 | 1.23 | 1.02, 1.47 | .03 |
HSV-2 | 0.83 | 0.70, 0.99 | .03 |
CMV | 0.69 | 0.57, 0.84 | .00 |
EBV | 0.95 | 0.79, 1.14 | .56 |
VZV | 1.09 | 0.92, 1.29 | .31 |
HHV-6 | 1.17 | 0.97, 1.42 | .10 |
Note: HSV-1, herpes simplex virus type 1; HSV-2, herpes simplex virus type 2; CMV, cytomegalovirus; EBV, Epstein-Barr virus; VZV, varicella-zoster virus; HHV-6, human herpes virus type 6.
aAdjusted for age, hospitalization status, years of service, and temporal relationship to diagnosis.
Hazard ratio expressed per 1 SD increase of each agent antibody level.