Table 1.
Summary of meta-analyses of published studies on selected variants and gastric cancer risk.
| Genes and variants | Modelsa | No. of Cases/Controls | OR (95% CI) | References |
|---|---|---|---|---|
| IL1B-31 (T→C) | Homozygote comparison | 1883/3220 | 0.95 (0.76–1.18) | 22, 23, 25, 26, 29, 30,32–38, 40, 41, 43–48 |
| Dominant model | 3476/5788 | 0.96 (0.80–1.14) | ||
| Recessive model | 3476/5788 | 0.98 (0.83–1.16) | ||
|
| ||||
| IL1B-511 (C→T) | Homozygote comparison | 1813/2370 | 1.19 (0.93–1.53) | 22, 24, 26–35, 37,39–42, 44, 46, 48 |
| Dominant model | 3663/4594 | 1.10 (0.92–1.32) | ||
| Recessive model | 3663/4594 | 1.15 (0.94–1.40) | ||
|
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| IL1RN (L→S)b | SS vs. LL | 2799/4355 | 1.42 (0.90–2.25) | 22–27, 29, 31, 33–35, 37–47 |
| Dominant model | 3749/5905 | 1.23 (1.02–1.48) | ||
| Recessive model | 3749/5905 | 1.33 (0.82–2.15) | ||
|
| ||||
| TNF-α-308 (G→A) | Homozygote comparison | 2279/3721 | 1.27 (0.91–1.77)c | 24, 27, 29, 35, 38, 42, 45, 46, 48, 55–61 |
| Dominant model | 2789/4497 | 1.06 (0.87–1.28) | ||
| Recessive model | 2789/4497 | 1.23 (0.89–1.72)c | ||
| Homozygote comparison | 792/930 | 0.92 (0.59–1.42)c,d | 64–72 | |
|
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| CYP2E1-1053 (C→T) | Dominant model | 1248/1762 | 0.78 (0.67–0.92)c | |
| Recessive model | 995/1368 | 0.98 (0.64–1.50)c,d | ||
| GSTM1 null genotype | Null genotype vs. non-null genotype | 3339/6273 | 1.33 (1.16–1.52) | 72, 74–97 |
| P53 R72P (G→C) | Homozygote comparison | 534/731 | 0.86 (0.66–1.11)c | 121–128 |
| Dominant model | 1077/1387 | 0.98 (0.82–1.18)c | ||
| Recessive model | 1077/1387 | 0.81 (0.65–1.00)c | ||
| Homozygote comparison | 740/722 | 1.04 (0.51–2.11) | 131–136 | |
| CDH1-160 (C→A) | Dominant model | 1287/1240 | 1.05 (0.81–1.37) | |
| Recessive model | 1287/1240 | 0.99 (0.52–1.87) | ||
a Homozygote comparison: variant homozygotes were compared with wild-type homozygotes; dominant model: a single variant allele was assumed to have a dominant effect; ie, both heterozygotes and variant homozygotes were at risk, compared with wild-type homozygotes; recessive model: only variant homozygotes (having both variant alleles) were at risk, compared with variant heterozygotes and wild-type homozygotes. [143]
b S: ILRN*2; L: other alleles.
c The fixed model (P > .05 for heterogeneity test); otherwise, the random model was used.
d CYP2E1-1053 (C→T): recessive model/homozygote comparison [64–68, 70–71]