Table 1.
Representative chemokines and their receptors
| Chemokine | Old Name | Receptors | Cellular targets |
|---|---|---|---|
| CXCL1 | Groα | CXCR20 | Neutrophils, EC |
| CXLC2 | MIP-2 | CXCR2 | Neutrophils, EC |
| CXCL5 | LIX | CXCR2 | Neutrophils |
| CXCL8 | IL-8 | CXCR1/CXCR2 | Neutrophils, EC |
| CXCL9 | Mig | CXCR3 | Th1 cells, EC |
| CXCL10 | IP-10 | CXCR3 | Th1 cells, EC |
| CXCL11 | I-TAC | CXCR3 | Th1 cells, EC |
| CXCL12 | SDF-1 | CXC4 | Bone marrow cells, Hematopoietic cells |
| CXCL13 | BCA-1 | CXCR5 | B cells, T helper cells |
| CCL1 | TCA-3 | CCR8 | Th17 and Th2 cells |
| CCL2 | MCP-1 | CCR1 | Monocytes/macrophages T cells |
| CCL3 | MIP-1α | CCR3/CCR5 | Monocytes/macrophages T cells, neutrophils |
| CCL4 | MIP-1β | CCR5 | Monocytes/macrophages T cells, neutrophils |
| CCL5 | RANTES | CCR1, CCR3, CCR5 | Monocytes/macrophages T cells, neutrophils |
| CCL11 | Eotaxin | CCR3 | Eosinophils |
| CCL17 | TARC | CCR4 | Th2 cells |
| CCL19 | ELC | CCR7 | DC, naïve T cells |
| CCL21 | SLC | CCR7 | DC, naïve T cells |
| CCL22 | MDC | CCR4 | Th2 cells, DC |
| CCL27 | CTACK | CCR10 | CD4 T cells |
Abbreviation: EC, Endothelial cells.