. Author manuscript; available in PMC: 2009 Jan 28.

Published in final edited form as: Pharm Res. 2007 Aug 3;25(3):700–708. doi: 10.1007/s11095-007-9344-y

Table I.

Sequence, Molecular Weight, and Nominal Distance Between Glutamic Acid Residues for each of the Sequences Studied

Designation^a	Repeat Sequence	MW (Da)^b	Approx. Spacing^c(Å)	A:Q	# of E
17-H-3	[AAAQEAAAAQAAAQAEAAQAAQ]₃	8,875	17	3:1	6
17-H-6^d	[AAAQEAAAAQAAAQAEAAQAAQ]₆	14,770	17	3:1	12
35-H-6	[AAAQAAQAQAAAEAAAQAAQAQ]₆	14,159	35	5:2	6

The designation, Y-H-X, indicates spacing between E residues (Y), α-helical backbone structure (H), and number of sequence repeats (X).

Theoretical molecular weight based on molecular weights of individual amino acids.

Spacing between E residues in an α-helical structure estimated via energy minimization calculations as previously reported (15,16).

Amino acid analysis, MALDI and HPLC results for 17-H-6 shown in the Electronic Supplementary Material.